August 1, 2025

Dr. Dirk Thye
Chief Executive Officer, Chief Medical Officer and Director
Quince Therapeutics, Inc.
611 Gateway Boulevard, Suite 273
South San Francisco, CA 94080

       Re: Quince Therapeutics, Inc.
           Registration Statement on Form S-3
           Filed July 25, 2025
           File No. 333-288971
Dear Dr. Dirk Thye:

       This is to advise you that we have not reviewed and will not review your
registration
statement.

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact Daniel Crawford at 202-551-7767 with any questions.



                                                           Sincerely,

                                                           Division of
Corporation Finance
                                                           Office of Life
Sciences
cc:   Gordon Ho, Esq.