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SEC FORM 3 SEC Form 3
FORM 3 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940 		 
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1. Name and Address of Reporting Person*
LAMOND PIERRE
(Last) (First) (Middle)
C/O CORTEXYME
269 EAST GRAND AVE.
(Street)
SOUTH SAN FRANCISCO CA 94080
(City) (State) (Zip)
2. Date of Event Requiring Statement (Month/Day/Year)
05/08/2019 		3. Issuer Name and Ticker or Trading Symbol
Cortexyme, Inc. [ CRTX ]
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director X 10% Owner
Officer (give title below) Other (specify below)
5. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
Form filed by One Reporting Person
X Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock 0 D
Table II - Derivative Securities Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4) 2. Date Exercisable and Expiration Date (Month/Day/Year) 3. Title and Amount of Securities Underlying Derivative Security (Instr. 4) 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 6. Nature of Indirect Beneficial Ownership (Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Series A Redeemable Convertible Preferred Stock (1) (1) Common Stock 500,483 (1) I By Christine E. Lamond 2019 Annuity Trust A dated March 4, 2019(2)
Series A Redeemable Convertible Preferred Stock (1) (1) Common Stock 500,482 (1) I By Pierre R. Lamond 2019 Annuity Trust A dated March 4, 2019(3)
Series A Redeemable Convertible Preferred Stock (1) (1) Common Stock 961,510 (1) I By Pierre R. and Christine E. Lamond Trust 11-22-85(4)
Series B Redeemable Convertible Preferred Stock (5) (5) Common Stock 462,027 (5) I By Christine E. Lamond 2019 Annuity Trust A dated March 4, 2019(2)
Series B Redeemable Convertible Preferred Stock (5) (5) Common Stock 462,028 (5) I By Pierre R. Lamond 2019 Annuity Trust A dated March 4, 2019(3)
1. Name and Address of Reporting Person*
LAMOND PIERRE
(Last) (First) (Middle)
C/O CORTEXYME
269 EAST GRAND AVE.
(Street)
SOUTH SAN FRANCISCO CA 94080
(City) (State) (Zip)
1. Name and Address of Reporting Person*
Lamond Christine
(Last) (First) (Middle)
C/O CORTEXYME
269 EAST GRAND AVE.
(Street)
SOUTH SAN FRANCISCO CA 94080
(City) (State) (Zip)
Explanation of Responses:
1. The Series A Redeemable Convertible Preferred Stock is convertible into the issuer's common stock on a one-for-one basis and has no expiration date. It will automatically convert into common stock upon the closing of the issuer's initial public offering.
2. Christine E. Lamond is the trustee of the Christine E. Lamond 2019 Annuity Trust A dated March 4, 2019, and has sole voting and dispositive power with respect to the shares held of record by the Christine E. Lamond 2019 Annuity Trust A dated March 4, 2019.
3. Pierre R. Lamond is the trustee of the Pierre R. Lamond 2019 Annuity Trust A dated March 4, 2019, and has sole voting and dispositive power with respect to the shares held of record by the Pierre R. Lamond 2019 Annuity Trust A dated March 4, 2019.
4. Pierre R. Lamond is the trustee of the Pierre R. and Christine E. Lamond Trust 11-22-85, and has sole voting and dispositive power with respect to the shares held of record by the Pierre R. and Christine E. Lamond Trust 11-22-85.
5. The Series B Redeemable Convertible Preferred Stock is convertible into the issuer's common stock on a one-for-one basis and has no expiration date. It will automatically convert into common stock upon the closing of the issuer's initial public offering.
Remarks:
Exhibit 24.1: Power of Attorney of Pierre Lamond Exhibit 24.2: Power of Attorney of Christine Lamond
/s/ Christopher Lowe, as Attorney-in-Fact for Pierre Lamond 05/08/2019
/s/ Christopher Lowe, as Attorney-in-Fact for Christine Lamond 05/08/2019
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
Exhibit 24.1

POWER OF ATTORNEY
The undersigned as a Section 16 reporting person of Cortexyme, Inc. (the
"Company"), hereby constitutes and appoints Christopher Lowe, Kristen Gafric and
Casey Lynch, and each of them, the undersigned's true and lawful attorney in
fact to:

(1)	execute, deliver and file for and on behalf of the undersigned, in the
undersigned's capacity as an officer and/or director of  the Company, Forms 3,
4, and 5 in accordance with Section 16(a) of the Exchange Act;

(2)	do and perform any and all acts for and on behalf of the undersigned which
may be necessary or desirable to complete and execute any such Form 3, 4, or 5,
complete and execute any amendment or amendments thereto, and timely file such
form with the SEC and any stock exchange or similar authority;

(3)	seek or obtain, as the undersigned's representative and on the undersigned's
behalf, information on transactions in the Company's securities from any third
party, including brokers, employee benefit plan administrators and trustees, and
the undersigned hereby authorizes any such person to release any such
information to the undersigned and approves and ratifies any such release of
information; and

(4)	take any other action of any type whatsoever in connection with the
foregoing which, in the opinion of such attorney in fact, may be of benefit to,
in the best interest of, or legally required by, the undersigned, it being
understood that the documents executed by such attorney in fact on behalf of the
undersigned pursuant to this Power of Attorney shall be in such form and shall
contain such terms and conditions as such attorney in fact may approve in such
attorney in fact's discretion.

The undersigned hereby grants to each such attorney in fact full power and
authority to do and perform any and every act and thing whatsoever requisite,
necessary, or proper to be done in the exercise of any of the rights and powers
herein granted, as fully to all intents and purposes as the undersigned might or
could do if personally present, with full power of substitution or revocation,
hereby ratifying and confirming all that such attorney in fact, or such attorney
in fact's substitute or substitutes, shall lawfully do or cause to be done by
virtue of this power of attorney and the rights and powers herein granted.  The
undersigned acknowledges that the foregoing attorneys in fact, in serving in
such capacity at the request of the undersigned, are not assuming, nor is the
Company assuming, any of the undersigned's responsibilities to comply with
Section 16 of the Exchange Act.  The undersigned further acknowledges and agrees
that the attorney-in-fact and the Company are relying on written and oral
information provided by the undersigned to complete such forms and the
undersigned is responsible for reviewing the completed forms prior to their
filing.  The attorney-in-fact and the Company are not responsible for any errors
or omissions in such filings.  The attorney-in-fact and the Company are not
responsible for determining whether or not the transactions reported could be
matched with any other transactions for the purpose of determining liability for
short-swing profits under Section 16(b).

This Power of Attorney shall remain in full force and effect until the
undersigned is no longer required to file Forms 3, 4, and 5 with respect to the
undersigned's holdings of and transactions in securities issued by the Company,
unless earlier revoked by the undersigned in a signed writing delivered to the
Company and the foregoing attorneys in fact.
IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be
executed as of this 15th day of February, 2019.

/s/ Pierre Lamond
Signature

Pierre Lamond
Print Name


Exhibit 24.2

POWER OF ATTORNEY

The undersigned as a Section 16 reporting person of Cortexyme, Inc. (the
"Company"), hereby constitutes and appoints
Christopher Lowe, Kristen Gafric and Casey Lynch, and each of them, the
undersigned's true and lawful attorney in fact to:

(1)	execute, deliver and file for and on behalf of the undersigned, in the
undersigned's capacity as an officer and/or director of the Company,
Forms 3, 4, and 5 in accordance with Section 16(a) of the Exchange Act;

(2)	do and perform any and all acts for and on behalf of the undersigned which
may be necessary or desirable to complete and execute
any such Form 3, 4, or 5, complete and execute any amendment or amendments
thereto, and timely file such form with the SEC and any
stock exchange or similar authority;

(3)	seek or obtain, as the undersigned's representative and on the undersigned's
behalf, information on transactions in the Company's securities
from any third party, including brokers, employee benefit plan administrators
and trustees, and the undersigned hereby authorizes any such person to release
any such information to the undersigned and approves and ratifies any such
release of information; and

(4)	take any other action of any type whatsoever in connection with the
foregoing which, in the opinion of such attorney in fact,
may be of benefit to, in the best interest of, or legally required by, the
undersigned, it being understood that the documents executed by
such attorney in fact on behalf of the undersigned pursuant to this Power of
Attorney shall be in such form and shall contain such terms and
conditions as such attorney in fact may approve in such attorney in fact's
discretion.

The undersigned hereby grants to each such attorney in fact full power and
authority to do and perform any
and every act and thing whatsoever requisite, necessary, or proper to be done in
the exercise of any of the
rights and powers herein granted, as fully to all intents and purposes as the
undersigned might or could do
if personally present, with full power of substitution or revocation, hereby
ratifying and confirming all that
such attorney in fact, or such attorney in fact's substitute or substitutes,
shall lawfully do or cause to be done
by virtue of this power of attorney and the rights and powers herein granted.
The undersigned acknowledges that the
foregoing attorneys in fact, in serving in such capacity at the request of the
undersigned, are not assuming,
nor is the Company assuming, any of the undersigned's responsibilities to comply
with Section 16 of the Exchange Act.

The undersigned further acknowledges and agrees that the attorney-in-fact and
the Company are relying
on written and oral information provided by the undersigned to complete such
forms and the undersigned
is responsible for reviewing the completed forms prior to their filing.
The attorney-in-fact and the Company  are not responsible for any errors or
omissions in such filings.
The attorney-in-fact and the Company are not responsible for determining whether
or not the transactions
reported could be matched with any other transactions for the purpose of
determining liability for short-swing profits under Section 16(b).

This Power of Attorney shall remain in full force and effect until the
undersigned is no longer required
to file Forms 3, 4, and 5 with respect to the undersigned's holdings of and
transactions in securities issued by the Company,
unless earlier revoked by the undersigned in a signed writing delivered to the
Company and the foregoing attorneys in fact.
IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be
executed as of this 2nd day of May, 2019.

/s/ Christine Lamond
Signature

Christine Lamond
Print Name